Many large-lecture introductory science courses for nonscience majors do not have a lab component and hence do not provide much opportunity for students to engage in the practice of science. The author has developed a new instructional activity called Dorm Room Labs that enables students to conduct hands-on activities as homework (or dorm room work) to explore more deeply concepts covered in 100-level science courses. The labs focus on concepts relevant to many physical science courses and consist of no-cost or low-cost lab equipment or their smartphones, enabling their use in large-enrollment courses.